Panthenol (Provitamin B5)
What it is
Panthenol (dexpanthenol) is the alcohol form of pantothenic acid (vitamin B5), a water-soluble vitamin essential for coenzyme A synthesis. Upon topical application, panthenol is enzymatically converted to pantothenic acid within the epidermis, where it participates in fatty acid synthesis, lipid metabolism, and epithelial regeneration. Its dual humectant and emollient properties, combined with documented wound-healing enhancement, establish it as a foundational ingredient in barrier-supportive and post-procedural formulations.
What it helps with
- Providing deep, lasting hydration through humectant action
- Accelerating epithelial regeneration and wound closure
- Reducing transepidermal water loss (TEWL)
- Calming irritation and reducing subjective discomfort
- Supporting lipid barrier synthesis and repair
- Exhibiting mild anti-inflammatory effects
Common concerns it addresses
Best for
Clinical suitability
- Indicated for post-procedural skincare (laser, peels, microneedling)
- Appropriate during topical retinoid therapy
- Suitable for patients with atopic tendencies
- Beneficial for acute irritation from environmental factors
- Safe during pregnancy and lactation
Use with caution
- Rare reports of contact sensitisation exist — patch test if extensive history of allergic reactions
- In occlusive formulations, may contribute to milia in susceptible individuals
Not ideal for
- Those expecting therapeutic action on specific concerns (acne, pigmentation) — panthenol supports but doesn't treat
- Patients requiring aggressive exfoliation or active intervention
How it's commonly used
Panthenol is formulated across virtually all product categories — cleansers, toners, serums, moisturisers, and intensive treatments — typically at concentrations of 1-5%. Its excellent tolerability permits twice-daily application without concern for irritation. Particularly valuable during periods of skin stress: post-procedure, during retinoid initiation, following sun exposure, or when barrier function is compromised. Often included in formulations designed to offset the drying effects of active ingredients.
Pairs well with
Clinic note
Panthenol consistently earns its place in our post-procedural protocols and in regimens for patients with chronically reactive skin. Its ability to accelerate epithelial healing while simultaneously providing non-occlusive hydration makes it uniquely versatile. We recommend panthenol-containing products during retinoid initiation to mitigate dryness and irritation, and routinely advise patients to keep a panthenol-rich product on hand for periods of acute sensitivity.
Ingredient-focused product examples
Clinically curated examples featuring this ingredient. These are optional references to help guide your product research.
Soothing Recovery Serum
Gentle hydrating serum formulated to calm irritated skin and support the healing process.
View productPost-Treatment Comfort Cream
Rich moisturiser designed to nourish and protect skin recovering from professional treatments.
View productThis content is provided for educational purposes and does not replace personalised medical advice. Individuals with skin conditions, those who are pregnant, or those undergoing dermatological treatments should seek professional guidance before introducing new active ingredients.
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