Hyaluronic Acid
What it is
Hyaluronic acid (HA) is an endogenous glycosaminoglycan distributed throughout connective, epithelial, and neural tissues. Its exceptional hygroscopic capacity — binding up to 1,000 times its molecular weight in water — makes it fundamental to dermal hydration and viscoelasticity. In topical formulations, molecular weight significantly influences efficacy: high molecular weight HA (>1,000 kDa) forms a hydrating film on the stratum corneum, while low molecular weight HA (<50 kDa) penetrates more deeply to provide intrinsic hydration and may stimulate keratinocyte proliferation.
What it helps with
- Providing multi-level hydration from the stratum corneum to deeper epidermal layers
- Plumping superficial dehydration lines and improving skin turgor
- Creating a hydrated microenvironment that optimises the penetration of other actives
- Supporting wound healing through moisture retention and cell migration
- Reducing transepidermal water loss when sealed with appropriate occlusives
- Improving overall skin texture and suppleness
Common concerns it addresses
Best for
Clinical suitability
- Universally appropriate across all Fitzpatrick skin types
- Indicated for patients on drying acne medications (isotretinoin, adapalene)
- Beneficial during and after cosmetic procedures (chemical peels, laser, microneedling)
- Suitable for eczema-prone individuals as part of a barrier-repair regimen
- Safe during pregnancy and lactation
Use with caution
- In very dry or low-humidity environments, ensure adequate occlusive follow-up
- Some individuals may experience transient congestion with very low molecular weight HA
- Cross-linked HA products differ significantly from standard topical HA — ensure appropriate formulation selection
Not ideal for
- As a standalone product without occlusive follow-up in arid climates
- Those expecting moisturising effects without complementary emollient use
How it's commonly used
HA is formulated in serums, essences, sheet masks, and moisturisers. For optimal efficacy, apply to damp skin to provide water for the humectant to bind. Follow immediately with an emollient or occlusive moisturiser to prevent transepidermal water loss. In arid environments, HA may draw moisture from deeper skin layers if not properly sealed — always layer appropriately. Multi-weight HA formulations offer comprehensive hydration across skin strata.
Pairs well with
Clinic note
We consider hyaluronic acid foundational to virtually every skincare protocol. Patients frequently misunderstand HA as a moisturiser when it is fundamentally a humectant requiring occlusive follow-up. We consistently observe improved tolerance to retinoids and acids when patients incorporate multi-weight HA formulations. Post-procedure, HA-rich products accelerate recovery and reduce the subjective sensation of tightness.
Ingredient-focused product examples
Clinically curated examples featuring this ingredient. These are optional references to help guide your product research.
BELANTTI Vitamin B5 Hydrating Serum 5% + Hyaluronic Acid 30ml
Combines 5% Panthenol with Hyaluronic Acid to support skin hydration, comfort and a smoother-looking texture. Lightweight formula designed for daily use across all skin types.
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WELLAGE Hyaluronic Acid Ampoule – Intensive Hydration Serum
Fast-absorbing Korean skincare ampoule formulated to deliver intense hydration. Helps skin feel plumper and look smoother without heaviness. Suitable for dehydrated, tight-feeling or dull-looking skin.
View productThis content is provided for educational purposes and does not replace personalised medical advice. Individuals with skin conditions, those who are pregnant, or those undergoing dermatological treatments should seek professional guidance before introducing new active ingredients.
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